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8 mei 2024

Nanopore approaches to single-molecule proteomics: From protein sequence to enzyme dynamics

Giovanni Maglia

Biophysical Journal

Nanopore approaches to single-molecule proteomics: From protein sequence to enzyme dynamics

2 mei 2024

Allostery can convert binding free energies into concerted domain motions in enzymes

Giovanni Maglia, Nicole Galenkamp, Sarah Zernia, Yulan Van Oppen, Andreas Milias-Argeitis

preprint

Allostery can convert binding free energies into concerted domain motions in enzymes

8 feb. 2024

Terminal tagging of full-length proteins for enhanced capturing by biological nanopores

Zhang, Zhuoyu ; Bloch, Dylan ; Yu, Luning ; Chen, Yu ; Kang, Xinqi ; Makhamreh, Amr K. ; Foster, Joshua C. ; Maglia, Giovanni ; Chen, Min ; Wanunu, Meni

Biophysical Journal,

Terminal tagging of full-length proteins for enhanced capturing by biological nanopores

6 feb. 2024

Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein

Jana Volarić, Nieck J. van der Heide, Natalie L. Mutter, Douwe F. Samplonius, Wijnand Helfrich, Giovanni Maglia*, Wiktor Szymanski*, and Ben L. Feringa*

ACS Chem. Biol.

Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein

23 jan. 2024

Unravelled proteins form blobs during translocation across nanopores

Adina Sauciuc, Jacob Whittaker, Matthijs Tadema, Kasia Tych, Albert Guskov, Giovanni Maglia

bioRxiv

Unravelled proteins form blobs during translocation across nanopores

19 dec. 2023

Engineered nanopores for exopeptidase protein sequencing

Andrea Bonini, Adina Sauciuc, Giovanni Maglia

Nature Methods

Engineered nanopores for exopeptidase protein sequencing

17 dec. 2023

Hydrophobically gated memristive nanopores for neuromorphic applications

Gonçalo Paulo, Ke Sun, Giovanni Di Muccio, Alberto Gubbiotti, Blasco Morozzo della Rocca, Jia Geng, Giovanni Maglia, Mauro Chinappi, Alberto Giacomello

Nature Communications

Hydrophobically gated memristive nanopores for neuromorphic applications

18 okt. 2023

Translocation of linearized full-length proteins through an engineered nanopore under opposing electrophoretic force

Adina Sauciuc, Blasco Morozzo della Rocca, Matthijs Tadema, Mauro Chinappi and Giovanni Maglia

Nature Biotechnology

Translocation of linearized full-length proteins through an engineered nanopore under opposing electrophoretic force

15 aug. 2023

Seeing the invisibles: detection of peptide enantiomers, diastereomers, and isobaric ring formation in lanthipeptides using nanopores

Roderick Corstiaan Abraham Versloot, Patricia Arias-Orozco, Matthijs Jonathan Tadema, Florian Leonardus Rudolfus Lucas, Xinghong Zhao, Siewert J. Marrink, Oscar Paul Kuipers, Giovanni Maglia

JACS

Seeing the invisibles: detection of peptide enantiomers, diastereomers, and isobaric ring formation in lanthipeptides using nanopores

17 jul. 2023

Protein sizing with 15-nm conical biological nanopore YaxAB

Sabine Straathof, Giovanni Di Muccio2, Maaruthy Yelleswarapu, Melissa Alzate Banguero2, Carsten Wloka, Nieck Jordy van der Heide, Mauro Chinappi and Giovanni Maglia

ACS Nano

Protein sizing with 15-nm conical biological nanopore YaxAB

1 mei 2023

Specific Detection of Proteins by a Nanobody-Functionalized Nanopore Sensor

Xialin Zhang, Nicole Stéphanie Galenkamp, Nieck Jordy van der Heide, Julián Moreno, Giovanni Maglia*, and Jørgen Kjems*

ACS nano

Specific Detection of Proteins by a Nanobody-Functionalized Nanopore Sensor

26 sep. 2022

Nanopore-based technologies beyond DNA sequencing

Yi-Lun Ying, Zheng-Li Hu, Shengli Zhang, Yujia Qing, Alessio Fragasso, Giovanni Maglia, Amit Meller, Hagan Bayley, Cees Dekker and Yi-Tao Long

Nature Nanotechnology

Nanopore-based technologies beyond DNA sequencing

19 jul. 2022

Unbiased Data Analysis for the Parameterization of Fast Translocation Events through Nanopores.

Lucas FLR , Willems K, Tadema MJ, Tych KM, Maglia G, Wloka C.

ACS Omega

Unbiased Data Analysis for the Parameterization of Fast Translocation Events through Nanopores.

28 jun. 2022

Quantification of Protein Glycosylation Using Nanopores

Versloot RCA, Lucas FLR, Yakovlieva L, Tadema MJ, Zhang Y, Wood TM, Martin NI, Marrink SJ, Walvoort MTC, Maglia G.

ACS Nano

Quantification of Protein Glycosylation Using Nanopores

27 jun. 2022

PlyAB Nanopores Detect Single Amino Acid Differences in Folded Haemoglobin from Blood

Dr. Gang Huang, Aderik Voorspoels, Roderick Corstiaan Abraham Versloot, Nieck Jordy van der Heide, Prof. Dr. Enrico Carlon, Dr. Kherim Willems, Prof. Dr. Giovanni Maglia

Angewandte Chemie International Edition

PlyAB Nanopores Detect Single Amino Acid Differences in Folded Haemoglobin from Blood

17 mrt. 2022

β-Barrel Nanopores with an Acidic-Aromatic Sensing Region Identify Proteinogenic Peptides at Low pH

Versloot RCA, Straathof SAP, Stouwie G, Tadema MJ, Maglia G.

ACS Nano

β-Barrel Nanopores with an Acidic-Aromatic Sensing Region Identify Proteinogenic Peptides at Low pH

7 mrt. 2022

Hypothesis-Driven, Structure-Based Design in Photopharmacology: The Case of eDHFR Inhibitors

Kobauri P, Galenkamp NS, Schulte AM, de Vries J, Simeth NA, Maglia G, Thallmair S, Kolarski D, Szymanski W, Feringa BL.

J. Med. Chem.

Hypothesis-Driven, Structure-Based Design in Photopharmacology: The Case of eDHFR Inhibitors

4 jan. 2022

Single-molecule sampling of dihydrofolate reductase shows kinetic pauses and an endosteric effect linked to catalysis

Galenkamp NS, and Maglia, G.

ACS Catalysis

Single-molecule sampling of dihydrofolate reductase shows kinetic pauses and an endosteric effect linked to catalysis

17 nov. 2021

Bottom-up fabrication of a proteasome–nanopore that unravels and processes single proteins

Zhang S, Huang G, Versloot RCA, Bruininks BMH, Telles de Souza PC, Marrink SJ and Maglia G.

Nature Chemistry

Bottom-up fabrication of a proteasome–nanopore that unravels and processes single proteins

21 okt. 2021

In silico assessment of a novel single-molecule protein fingerprinting method employing fragmentation and nanopore detection

de Lannoy C, Lucas FLR, Maglia G, de Ridder D.

iScience

In silico assessment of a novel single-molecule protein fingerprinting method employing fragmentation and nanopore detection
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