Job description
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Qualifications
What you will do
_____________________________________________________________
Engineer and characterise biological nanopores for the detection, identification and analysis of proteins and peptides, building on the Maglia lab's nanopore sensing and electro-osmotic sequencing platforms.
Collaborate with VUB-VIB to test, validate and adapt de novo-designed protein nanopores for functional single-molecule sensing applications.
Collaborate with imec on the integration of biological/de novo nanopores with solid-state platforms towards scalable, hybrid nanopore devices.
Design and perform single-molecule experiments (electrical recordings, possibly combined with optical/fluorescence readouts) to characterise pore behaviour and sensing performance.
Contribute to project management and valorisation activities alongside the consortium partners, including reporting to the funding body and engagement with industrial stakeholders.
Publish and present your findings in peer-reviewed journals and at international conferences, and contribute to supervising PhD students and junior lab members.
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What we are looking for
_____________________________________________________________
A PhD in Biochemistry, Chemistry, Biophysics, Molecular Biology, Bionanotechnology or a related field, completed or nearly completed.
Demonstrated experience with protein engineering, expression and purification; experience with membrane proteins, ion channels or nanopores is a strong advantage.
Experience with single-molecule biophysical techniques (e.g. electrical/electrophysiological recordings, single-channel analysis, fluorescence-based single-molecule methods) is highly desirable.
A strong record of scientific output relative to career stage (publications, conference contributions).
Willingness to collaborate closely with partner labs in Brussels (VUB-VIB) and Leuven (imec), including travel for joint experiments and consortium meetings.
Good written and spoken English; strong communication, organisational and mentoring skills.
Organisation
Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative institution of higher education offering high-quality teaching and research. Flexible study programmes and academic career opportunities in a wide variety of disciplines encourage the 36,000 students and researchers alike to develop their own individual talents. As one of the best research universities in Europe, the University of Groningen has joined forces with other top universities and networks worldwide to become a truly global center of knowledge.
Conditions of employment
What we offer
_____________________________________________________________
A fully-funded postdoctoral position within an ambitious, cross-disciplinary consortium spanning computational protein design, biological nanopore science and solid-state nanofabrication.
The opportunity to work at the interface of academia and applied/industrial nanopore technology, with a direct line to valorisation partners.
Access to the Maglia lab's molecular biology, protein engineering/purification and single-molecule nanopore facilities, as well as RUG's structural biology infrastructure (cryo-EM, crystallography).
Close collaboration with the Vorobieva lab (VUB-VIB) and imec, two of Europe's leading groups in de novo protein design and solid-state nanopore fabrication respectively.
A stimulating, international research environment in Groningen, the Netherlands.
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How to apply
_____________________________________________________________
Please submit your application including (1) a motivation letter, (2) a full CV with publication list, and (3) the contact details of two references to chembio@rug.nl.
-
For informal enquiries about the project,
please contact Prof. Giovanni Maglia (chembio@rug.nl).
Post-doc
Maglia Lab, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen
Part of a Strategic Basic Research (SBO) consortium with VUB-VIB Center for Structural Biology and imecÂ
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About the project
_____________________________________________________________
This postdoctoral position is part of a multidisciplinary consortium project bringing together three partners at the forefront of nanopore science: the Vorobieva lab at the VUB-VIB Center for Structural Biology (Brussels), a pioneer in the de novo computational design of membrane proteins and nanopores from physical principles; the group of Prof. Giovanni Maglia at the University of Groningen, a world leader in biological nanopore engineering and single-molecule protein/peptide analysis; and imec (Leuven), a global leader in solid-state nanopore fabrication and hybrid nanopore-electronic integration.
Together, the consortium aims to combine de novo protein design, biological nanopore sensing and solid-state nanofabrication into a new generation of hybrid nanopore sensors for single-molecule protein and peptide analysis.
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The position in Groningen
_____________________________________________________________
The Maglia lab at the Groningen Biomolecular Sciences and Biotechnology Institute (GBB) is looking for a talented and motivated postdoctoral researcher to lead the Groningen contribution to this project. The lab has pioneered single-molecule nanopore enzymology and the use of electro-osmotic flow for sequencing proteins, and has extensive experience engineering biological nanopores for protein and peptide sensing, including nanobody-functionalised nanopores, nanopore peptide spectroscopy, and detection of proteins directly in biological fluids.
You will work at the interface of the consortium's expertise, engineering and characterising biological and hybrid nanopores for single-molecule protein/peptide sensing, and integrating de novo-designed pores (from VUB-VIB) and/or solid-state elements (from imec) into functional sensing platforms.
Qualifications
What you will do
_____________________________________________________________
Engineer and characterise biological nanopores for the detection, identification and analysis of proteins and peptides, building on the Maglia lab's nanopore sensing and electro-osmotic sequencing platforms.
Collaborate with VUB-VIB to test, validate and adapt de novo-designed protein nanopores for functional single-molecule sensing applications.
Collaborate with imec on the integration of biological/de novo nanopores with solid-state platforms towards scalable, hybrid nanopore devices.
Design and perform single-molecule experiments (electrical recordings, possibly combined with optical/fluorescence readouts) to characterise pore behaviour and sensing performance.
Contribute to project management and valorisation activities alongside the consortium partners, including reporting to the funding body and engagement with industrial stakeholders.
Publish and present your findings in peer-reviewed journals and at international conferences, and contribute to supervising PhD students and junior lab members.
-
What we are looking for
_____________________________________________________________
A PhD in Biochemistry, Chemistry, Biophysics, Molecular Biology, Bionanotechnology or a related field, completed or nearly completed.
Demonstrated experience with protein engineering, expression and purification; experience with membrane proteins, ion channels or nanopores is a strong advantage.
Experience with single-molecule biophysical techniques (e.g. electrical/electrophysiological recordings, single-channel analysis, fluorescence-based single-molecule methods) is highly desirable.
A strong record of scientific output relative to career stage (publications, conference contributions).
Willingness to collaborate closely with partner labs in Brussels (VUB-VIB) and Leuven (imec), including travel for joint experiments and consortium meetings.
Good written and spoken English; strong communication, organisational and mentoring skills.
Conditions of employment
What we offer
_____________________________________________________________
A fully-funded postdoctoral position within an ambitious, cross-disciplinary consortium spanning computational protein design, biological nanopore science and solid-state nanofabrication.
The opportunity to work at the interface of academia and applied/industrial nanopore technology, with a direct line to valorisation partners.
Access to the Maglia lab's molecular biology, protein engineering/purification and single-molecule nanopore facilities, as well as RUG's structural biology infrastructure (cryo-EM, crystallography).
Close collaboration with the Vorobieva lab (VUB-VIB) and imec, two of Europe's leading groups in de novo protein design and solid-state nanopore fabrication respectively.
A stimulating, international research environment in Groningen, the Netherlands.
-
How to apply
_____________________________________________________________
Please submit your application including (1) a motivation letter, (2) a full CV with publication list, and (3) the contact details of two references to chembio@rug.nl.
-
For informal enquiries about the project,
please contact Prof. Giovanni Maglia (chembio@rug.nl).
Organisation
Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative institution of higher education offering high-quality teaching and research. Flexible study programmes and academic career opportunities in a wide variety of disciplines encourage the 36,000 students and researchers alike to develop their own individual talents. As one of the best research universities in Europe, the University of Groningen has joined forces with other top universities and networks worldwide to become a truly global center of knowledge.